Saddest Video Game Moment?

Let's face it, video games have become a storytelling GIANT. Look at series like Final Fantasy and Metal Gear, both franchises have through gripping drama, plot twists and intricate character relationships have reeled us in and kept us wanting for more. If you're like me, your main concern is oftentimes the story (of course the gameplay has to be good as well)and just how much it pulls you in, there's even some that'll bring a tear to your eye, usually in one moment. Over the years both of these series and others have had moments like these, but there are many others, what do you guys think?